Micro- and nanoplastics (MNPs) have been found in every environmental compartment, in most food items and in various human organs. However, the impacts of MNPs on human health are still not quantified. This PhD project thus aims to first assess the impacts of MNPs on human toxicity and combine them with relevant MNP exposure through food ingestion. Ultimately, characterisation factors will thus be derived to include MNP impacts on human health in LCA impact methodologies, and consequently broadening LCIA coverage and improving LCA in its capacity as a decision-making tool.